I personally love Europe in March; coming out of a cold winter, the air is still slightly crisp at night, mild by day; more sun than rain, and best of all, a lack of tourists and plenty o' discounted hotel rooms.
United Airlines has great deals from S.F to Switzerland, Spain and other popular European destinations. But my pick is Istanbul; situated a bit further South, climatically favorable, perhaps a bit politically unfavorable, but nonetheless an exciting destination and for only $570 bucks. For those keeping track of miles (love ya!) that will net you about 7000 each way.
Visit united.com or farecompare.com